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Jak/Src Inhibitor 1 . hydrochloride

AG-CR1-3647-M001 1 mg INQ
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Product Data
Synonyms Debio 0617B . HCl; N-(4-Chloro-3-(2-((4-(methyl-carbamoyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl)-4-(trifluoromethyl)picolinamide
Properties
Formula C28H23ClF3N7O2 . HCl
MW 582.0 . 36.5
CAS 1332329-27-7 (parent)
Purity ≥97% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
InChi Key VQUNOHCOLZKQJY-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Multi-kinase inhibitor with potent antiproliferative anti-migratory activities.
  • Potent STAT3/5 inhibitor in vitro and in vivo.
  • Combined inhibitor of key kinases phosphorylating STAT3 and STAT5 proteins such as JAK, SRC, ABL families of kinases, and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.

Product References

  1. Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases: M. Murone, et al.; Mol. Cancer Ther. 15, 2334 (2016)
  2. The multi-kinase inhibitor Debio 0617B reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells: M. Murone, et al.; Mol. Cancer Ther. (Epub ahead of print) (2017)
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