Call +41-61-926-60-40 Fax +41-61-926-60-49

CK2 Inhibitor 10

AG-CR1-3626-M001 1 mg INQ
AG-CR1-3626-M005 5 mg INQ
Actions
Select size:

* Required Fields

Amount:
Add to Cart
Call +41-61-926-60-40
Fax +41-61-926-60-49
Contact Us!

Additional Information

Product Data
Synonyms CK2-VIII; 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
Properties
Formula C18H14N2O4S . 0.5H2O
MW 354.4 . 9.0
CAS 1361229-76-6
Purity ≥98% (HPLC, MS, NMR)
Appearance Off-white to pale yellow solid.
Solubility Soluble in DMSO. Insoluble in water.
InChi Key UPIVZLFKYMNZDG-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download Document Download

Product Description

  • Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2α=32nM and IC50 CK2α'=46nM).
  • Potently also inhibits DYRK1B and FLT3.
  • Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7.
  • Promoted cAMP-induced thermogenesis in white adipocytes.
  • CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.

Product References

  1. Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds: Z. Hou, et al.; J. Med. Chem. 55, 2899 (2012)
  2. Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure: K. Shinoda, et al.; Cell Metab. 22, 997 (2015)
No reviews for this product yet.