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AdipoGen Life Sciences
BLZ-945
50
CHF
CHF 50.00
In stock
AG-CR1-3609-M0011 mgCHF 50.00
AG-CR1-3609-M0055 mgCHF 110.00
AG-CR1-3609-M02525 mgCHF 420.00
| Product Details | |
|---|---|
| Synonyms | BLZ945 |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H22N4O3S |
| MW | 398.5 |
| CAS | 953769-46-5 |
| Purity Chemicals | ≥95% |
| Appearance | Pale yellow solid. |
| Solubility | Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. |
| InChi Key | ADZBMFGQQWPHMJ-RHSMWYFYSA-N |
| Smiles | CNC(=O)C1=CC(OC2=CC=C3N=C(N[C@@H]4CCCC[C@H]4O)SC3=C2)=CC=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticancer compound.
- Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R; c-Fms) inhibitor.
- More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor β (PDGFRβ).
- Selective against more than 200 additional kinases [2].
Product References
- Investigation of correlation among safety biomarkers in serum, histopathological examination, and toxicogenomics: T. Wang, et al.; Int. J. Toxicol. 30, 300 (2011)
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression: S.M. Pyonteck, et al.; Nat. Med. 19, 1264 (2013)
- CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells: D.C. Strachan, et al.; Oncoimmunology 2, e26968 (2013)
- Therapeutically reeducating macrophages to treat GBM: C. Garris & M.J. Pittet; Nat. Med. 19, 1207 (2013)
- Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite: J.A. Krauser, et al.; Xenobiotica 45, 107 (2015)
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