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AG-CR1-3603-M005 5 mg INQ
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Product Data
Synonyms Anaphase Promoting Complex Inhibitor
Formula C13H14Cl3N7O4
MW 438.7
CAS 300815-04-7
Purity ≥95% (LC/MS and NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO (20mM).
Origin Manufactured by Boston Biochem
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

  • Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis.
  • Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20.
  • Distinct mechanism of action than proTAME.
  • Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.

Product References

  1. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C: K.L. Sackton, et al.; Nature 514, 646 (2014)
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