AdipoGen Life Sciences

IHR-NAc

As low as CHF 80.00

In stock

Only %1 left

AG-CR1-3527-M0011 mgCHF 80.00

AG-CR1-3527-M0055 mgCHF 190.00

Specifications / Handling

More Information
Product Details
Synonyms	5-Acetamido-2-chloro-N-[4-(2,5-dichlorobenzamido)phenyl]benzamide
Product Type	Chemical
Properties
Formula	C₂₂H₁₆Cl₃N₃O₃
MW	476.7
CAS	2973769-90-1
Purity Chemicals	≥98% (NMR)
Appearance	White to grey solid.
Solubility	Soluble in DMSO.
Identity	Determined by ¹H-NMR and HR-MS.
InChi Key	KEKPTYABAFCFOT-UHFFFAOYSA-N
Smiles	CC(=O)NC1=CC=C(Cl)C(=C1)C(=O)NC1=CC=C(NC(=O)C2=C(Cl)C=CC(Cl)=C2)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound.
Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo.
Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Product-specific References

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)

Call	+41 61 926 6040
Fax	+41 61 926 6049