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AdipoGen Life Sciences
Tripolin A
120
CHF
CHF 120.00
In stock
AG-CR1-3520-M0011 mgCHF 120.00
AG-CR1-3520-M0055 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | (3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H11NO3 |
| MW | 253.3 |
| CAS | 1148118-92-6 |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO (at least 10 mg/ml). |
| Identity | Determined by 1H-NMR and HR-MS. |
| InChi Key | OMKSBDLWMROKNU-WQLSENKSSA-N |
| Smiles | OC1=CC=C(O)C(\C=C2/C(=O)NC3=C2C=CC=C3)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Specific non-ATP competitive Aurora A kinase inhibitor [1]. Does not significantly inhibit Aurora B kinase in mammalian cells.
- Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase [1].
Product References
- Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules: I.A. Kesisova, et al.; PLoS One 8, e58485 (2013)
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