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AdipoGen Life Sciences
SANT-2
50
CHF
CHF 50.00
In stock
AG-CR1-3514-M0011 mgCHF 50.00
AG-CR1-3514-M0055 mgCHF 115.00
| Product Details | |
|---|---|
| Synonyms | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H26ClN3O4 |
| MW | 480.0 |
| CAS | 329196-48-7 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, ethanol or chloroform. |
| Identity | Determined by 1H-NMR. |
| InChi Key | VQOJFGFKIVFMDH-UHFFFAOYSA-N |
| Smiles | CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC1=CC(C2=NC3=C(N2)C=CC=C3)=C(Cl)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Sonic hedgehog (Shh) signaling pathway modulator.
- Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo.
- SAG activity (Prod. Nr. AG-CR1-3506) inhibitor.
- Gli1 reporter gene expression inhibitor.
- Suppresses the Shh-dependent translocation of Smo to the primary cilium.
- Potential tumor growth blocker.
Product References
- Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)
- Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review)
- Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)
- Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009)
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. Büttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)
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