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Paprotrain

AG-CR1-3504-M001 1 mg INQ
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Additional Information

Product Data
Synonyms (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Properties
Formula C16H11N3
MW 245.3
CAS 57046-73-8
Purity ≥98% (NMR)
Appearance Yellow solid.
Solubility Soluble in DMSO (at least 5 mg/ml).
InChi Key YMYYQRZCCKBFBE-MDWZMJQESA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download Document Download
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Product Description

  • Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor [1].
  • Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation [1].
  • Moderate DYRK1A inhibitor (IC50= 5.5 μM). Lead compound [3].

Product References

  1. Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor: S. Tcherniuk, et al.; Angew. Chem. (Int'l Ed.) 49, 8228 (2010)
  2. New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations: C. Labrière, et al.; Bioorg. Med. Chem. 24, 721 (2016)
  3. Further investigation of paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors: C. Labrière, et al.; Eur. J. Med. Chem. 124, 920 (2016)
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