Call +41-61-926-60-40 Fax +41-61-926-60-49


AG-CR1-2902-M001 1 mg INQ
AG-CR1-2902-M005 5 mg INQ
AG-CR1-2902-M025 25 mg INQ
Select size:

* Required Fields

Add to Cart
Call +41-61-926-60-40
Fax +41-61-926-60-49
Contact Us!

Additional Information

Product Data
Synonyms [9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde; NSC 610970
Formula C28H18O2
MW 386.4
CAS 1176-09-6
Purity ≥98% (NMR)
Appearance Beige solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Other Product Data Note: Use fresh solutions. Cyclizes in water/acidic conditions.
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Keep under inert gas. Protect from moisture and oxygen.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download Document Download

Product Description

  • Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis.
  • Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4μM indicating activity across a wide range of cell lines.
  • Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.

Product References

  1. A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015)
No reviews for this product yet.