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BMS-3

AG-CR1-2901-M005 5 mg INQ
AG-CR1-2901-M025 25 mg INQ
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Additional Information

Product Data
Synonyms N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2- yl)cyclopropanecarboxamide
Properties
Formula C17H12Cl2F2N4OS
MW 429.3
CAS 1338247-30-5
Purity ≥98% (HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO (5mg/ml).
InChi Key YBGGBHCJSAEIAS-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

Potent LIMK (Lim kinase) inhibitor. Has IC50 values of 5nM and 6nM for LIMK1 and LIMK2, respectively.

Product References

  1. Phenyl-substituted pyrimidine compounds useful as kinase inhibitors: S.T. Wrobelski, et al.; WO2006084017 (2006)
  2. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors: P. Ross-Macdonald, et al.; Mol. Cancer Ther. 7, 3490 (2008)
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