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AdipoGen Life Sciences
Dynasore
55
CHF
CHF 55.00
In stock
AG-CR1-0045-M0055 mgCHF 55.00
AG-CR1-0045-M02525 mgCHF 195.00
| Product Details | |
|---|---|
| Synonyms |
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzyl- idene)-hydrazide . 0.5H2O |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H14N2O4 . 0.5H2O |
| MW | 322.3 . 9.0 |
| CAS |
304448-55-3 (free base) 1202867-00-2 (x H2O) |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Off-white solid. |
| Solubility | Soluble in 100% ethanol (1 mg/ml) or DMSO (10 mg/ml); insoluble in water. |
| Other Product Data |
Stock solutions are stable for up to 3 months when stored at -20°C. |
| InChi Key | SYNDQCRDGGCQRZ-VXLYETTFSA-N |
| Smiles | OC1=CC2=C(C=CC=C2)C=C1C(=O)N\N=C\C1=CC(O)=C(O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor [1].
- Endocytosis inhibitor [1, 2].
- Viral infection inhibitor [3].
- Destabilizes actin filaments [4].
- Inhibits entry of Trypanosoma into macrophages [5].
- Inhibitor of mitophagy.
- Inhibitor of hepatocyte lipophagy
Product References
- Dynasore, a cell-permeable inhibitor of dynamin.: E. Macia, et al. ; Dev. Cell. 10, 839 (2006)
- Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol. 438, 77 (2008)
- HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore: C.Y. Abban, et al.; Am. J. Ther. 15, 304 (2008)
- Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments: H. Yamada, et al.; BBRC 390, 1142 (2009)
- Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One 5, e7764 (2010)
- Mitochondrial dynamics and mitophagy in the 6-hydroxydopamine preclinical model of Parkinson's disease: M.F. Galindo, et al.; Parkinsons Dis. 131058 (2012)
- A well-oiled machine: DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly: RJ. Schulze & MA. McNiven; Autophagy 10, 388 (2013)
- Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT: R. Padmanabhan & L.A. Taneyhill; J. Cell Sci. 128, 1773 (2015)
- Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis: K. Inoue, et al.; Clin. Exper. Immunol., ahead of print (2019)
- Enhanced lysosomal degradation maintains the quiescent state of neural stem cells: T. Kobayashi, et al.; Nat. Comm. in press, (2019)