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(-)-Indolactam V

AG-CR1-0041-C300 300 µg INQ
AG-CR1-0041-M001 1 mg INQ
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Additional Information

Properties
Formula C17H23N3O2
MW 301.4
CAS 90365-57-4
RTECS UY8547000
Purity ≥97% (NMR)
Appearance Off-white to light yellow solid.
Solubility Soluble in DMSO or 100% ethanol.
Other Product Data May contain traces of (+)-Indolactam V.
InChi Key LUZOFMGZMUZSSK-LRDDRELGSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
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Product Description

  • Tumor promoter [1].
  • Protein kinase C (PKC) inducer [2].
  • Mitogenesis activator [3].
  • Differentiation inducer [4].

Product References

  1. Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann 75, 866 (1984)
  2. (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC 162, 1207 (1989)
  3. (-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways: N. Papadogiannakis; Cell. Immunol. 162, 288 (1995)
  4. A small molecule that directs differentiation of human ESCs into the pancreatic lineage: S. Chen, et al.; Nat. Chem. Biol. 5, 258 (2009)
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