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AdipoGen Life Sciences
AMI-1
120
CHF
CHF 120.00
In stock
AG-CR1-0038-M0055 mgCHF 120.00
AG-CR1-0038-M02525 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | Arginine N-methyltransferase inhibitor-1 |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H12N2O9S2Na4 |
| MW | 592.4 |
| CAS |
160994-87-6 (xNa) 134-47-4 (free base) |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | Brown solid. |
| Solubility | Soluble in water, 100% ethanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | OEJIOAHFKHHDAW-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[O-]C1=CC(=CC2=C1C=CC(NC(=O)NC1=CC3=C(C=C1)C([O-])=CC(=C3)S(=O)(=O)O[Na])=C2)S(=O)(=O)O[Na] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Hygroscopic. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 μM) [1].
- Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site [1].
- Blocks peptide substrate binding [3].
- HIV-1 RT polymerase inhibitor (IC50 = 5.0 μM) [2].
Product References
- Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004)
- A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002)
- Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)
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