AdipoGen Life Sciences

Ciglitazone

CHF 45.00
In stock
AG-CR1-0033-M0011 mgCHF 45.00
AG-CR1-0033-M0055 mgCHF 110.00
AG-CR1-0033-M02525 mgCHF 440.00
More Information
Product Details
Synonyms (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione; U-63287
Product Type Chemical
Properties
Formula

C18H23NO3S

MW 333.5
CAS 74772-77-3
RTECS XJ5813700
Purity Chemicals ≥98% (HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO or 100% ethanol.
Identity Determined by 1H-NMR.
Other Product Data

Stock solutions are stable for up to 3 months when stored at -20°C.

InChi Key YZFWTZACSRHJQD-UHFFFAOYSA-N
Smiles CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Selective PPARγ agonist (EC50=3 µM) [1].
  • Hypoglycemic agent [2, 3].
  • Angiogenesis inhibitor [4].
  • Anti-inflammatory [5].
  • Apoptosis inducer [6].
Product References
  1. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)
  2. Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32, 804 (1983)
  3.  [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
  4. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999)
  5. The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37, 614 (2009)
  6. Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3, 1 (2010)
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