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AdipoGen Life Sciences
1,5-Isoquinolinediol
35
CHF
CHF 35.00
In stock
AG-CR1-0024-M0055 mgCHF 35.00
AG-CR1-0024-M02525 mgCHF 80.00
AG-CR1-0024-M100100 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | 5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H7NO2 |
| MW | 161.2 |
| CAS | 5154-02-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (20mg/ml), DMF (20mg/ml), ethanol (10mg/ml) or methanol (5mg/ml). Insoluble in water. |
| InChi Key | LFUJIPVWTMGYDG-UHFFFAOYSA-N |
| Smiles | OC1=CC=CC2=C(O)N=CC=C12 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- PARP-1 inhibitor [1].
- Neuroprotectant [2].
- Blocks nitric oxide-induced neuronal toxicity [2].
- Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor [3].
- Stimulates homologous recombination [4].
Product References
- Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992)
- Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994)
- Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006)
- 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)
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