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SNC80

AG-CR1-0017-M005 5 mg INQ
AG-CR1-0017-M025 25 mg INQ
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Additional Information

Product Data
Synonyms (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Properties
Formula C28H39N3O2
MW 449.6
CAS 156727-74-1
Purity ≥99% (NMR)
Appearance White to off-white crystalline solid.
Solubility Soluble in 100% ethanol, DMSO or dichloromethane.
InChi Key KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
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Product Description

  • Highly selective and potent non-peptide δ-opioid receptor agonist [1-3].
  • Mediates downregulation of the δ-opioid receptor [4].
  • Shows antidepressant-like effects [5, 8].
  • Modulates voltage-dependent sodium channels [6].
  • Antinociceptive [7].
  • Activates ATP-sensitive K+ channels [7].
  • Enhances amphetamine-mediated dopamine efflux [9].

Product References

  1. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4- [(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994) 
  2. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995) 
  3. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp , et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996) 
  4. Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin: T. Okura, et al.; Eur. J. Pharmacol. 387, R11 (2000) 
  5. Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents: A. Saitoh, et al.; J. Pharmacol. Sci. 95, 374 (2004) 
  6. Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons: C. Remy, et al.; Neuropharmacology 47, 1102 (2004) 
  7. Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels: D.F. Pacheco & I.D. Duarte; Eur. J. Pharmacol. 512, 23 (2005) 
  8. Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model: A. Saitoh, et al.; Brain Res. 1208, 160 (2008) 
  9. The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum: K.E. Bosse, et al.; Neuropharmacology 55, 755 (2008)
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