AdipoGen Life Sciences

Ketanserin . tartrate

CHF 40.00
In stock
AG-CR1-0014-M01010 mgCHF 40.00
AG-CR1-0014-M05050 mgCHF 90.00
More Information
Product Details
Synonyms 3-[2-[4-(4-Fluorobenzoyl)-1-piperdinyl)ethyl]-2,4(1H,3H)-quinazolinedione tartrate
Product Type Chemical
Properties
Formula

C22H22FN3O3 . C4H6O6

MW 395.4 . 150.1
Merck Index 14: 5296
CAS 83846-83-7
RTECS VA1411195
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO; slightly soluble in water (4 mg/ml) or 100% ethanol (3 mg/ml).
InChi Key KMTLTEVOQLMYRS-UHFFFAOYSA-N
Smiles [CH2]C#CC.OOOOOO.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Selective 5-HT2A serotonin receptor antagonist [1].
  • ATP-sensitive potassium channel inhibitor [2]. 
  • hERG potassium channel blocker [3].
Product References
  1. Vascular activity of ketanserin (R 41 468), a selective 5-HT2 receptor antagonist: J.M. van Nueten, et al.; Arch. Int. Pharmacodyn. Ther. 250, 328 (1981) 
  2. Ketanserin, a 5-HT2 antagonist, directly inhibits the ATP-sensitive potassium channel in mouse ventricular myocytes: J.M. Ju, et al.; J. Cardiovasc. Pharmacol. 47, 96 (2006) 
  3. The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels: Q. Li, et al.; Br. J. Pharmacol. 155, 365 (2008) 
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.