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AdipoGen Life Sciences
BAY 11-7082
90
CHF
CHF 90.00
In stock
AG-CR1-0013-M01010 mgCHF 90.00
AG-CR1-0013-M05050 mgCHF 360.00
Inhibition of TNFα-induced genes by BAY 11-7082 (AG-CR1-0013). Methods: Endothelial cells (HUVEC) are incubated for 1h in the presence of BAY 11-7082 (AG-CR1-0013) and then treated with TNFα (20ng/ml) (red bar) or incubated with TNFα (20ng/ml) (in the presence or absence of TNF-R1 (human):Fc (human) (rec.) (0.5µg/ml) (blue and gray bar, respectively). TNFα-induced genes expression such as E-Selectin or MCP-1 are tested by flow cytometry. Picture courtesy of Giulia Vanoni (Dr. Camilla Jandus Lab, University of Lausanne).
| Product Details | |
|---|---|
| Synonyms | (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H9NO2S |
| MW | 207.3 |
| CAS | 19542-67-7 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | White to off-white crystalline solid. |
| Solubility | Soluble in DMSO, 100% ethanol, dichloromethane or ethyl acetate; insoluble in water. |
| InChi Key | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| Smiles | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- IκBα kinase inhibitor.
- NF-κB inhibitor.
- Potential anti-inflammatory agent.
- Apoptosis inducer.
- Inhibits the release of proinflammatory cytokines.
- NLRP3 inflammasome inhibitor. Reduces ATPase activity of the NLRP3 inflammasome.
- Inhibits platelet aggregation.
- RBR E3 ligase inhibitor. Effects by inactivating the E2-conjugating enzymes Ubc13 and UbcH7 and the E3 ligase LUBAC, preventing the formation of Lys63-linked and linear polyubiquitin chains.
Product References
- Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997)
- Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells: N. Mori, et al.; Blood 100, 1828 (2002)
- Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro: M. Lappas et al.; Endocrinology 146, 1491 (2005)
- Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome: C. Juliana, et al.; J. Biol. Chem. 285, 9792 (2010)
- A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations: H.S. Lee, et al.; Eur. J. Pharmacol. 627, 85 (2010)
- The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system: S. Strickson, et al.; Biochem. J. 451, 427 (2013)
- The impact of α-Lipoic acid on cell viability and expression of nephrin and ZNF580 in normal human podocytes: U. Leppert, et al.; Eur. J. Pharmacol. 810, 1 (2017)
- Inflammatory Signaling and DNA Damage Responses after Local Exposure to an Insoluble Radioactive Microparticle: Y. Matsuya, et al. Cancers 14, 1045 (2022)
- Exposure to Multi-Wall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis: T. Tsunematsu, et al.; Am. J. Pathol. ahead of print (2022)
- Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines: R. Owaki, et al.; Vet. Comp. Oncol. ahead of print (2023)
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