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AdipoGen Life Sciences
Bradykinin
35
CHF
CHF 35.00
In stock
AG-CP3-0025-M0055 mgCHF 35.00
AG-CP3-0025-M02525 mgCHF 130.00
| Product Details | |
|---|---|
| Synonyms | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH . TFA |
| Product Type | Chemical |
| Properties | |
| Formula |
C50H73N15O11 . C2HF3O2 |
| MW | 1060.2 . 114.0 |
| Sequence |
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH |
| Merck Index | 14: 1359 |
| CAS | 121283-65-6 | 58-82-2 (free base) |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Lyophilized powder. |
| Solubility | Soluble in water (5mg/ml). |
| InChi Key | WTRZIOCXFWDHEM-MIEKKPBHSA-N |
| Smiles | [O-]C(=O)C(F)(F)F.N[C@@H](CCCNC([NH3+])=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Pro-inflammatory peptide, acting through G-protein-coupled receptors.
- Endogenous bradykinin receptor agonist that displays selectivity for B2 over B1 receptors.
- Endogenously formed following pathophysiological stimuli such as inflammation, tissue damage or anoxia.
- Activator of endothelial nitric oxide synthase (eNOS; NOS III). Reduces blood pressure by inducing the release of prostacyclin, nitric oxide and endothelium-derived hyperpolarizing factor.
- Plays an important role in the regulation of fluid and electrolyte balance, non-vascular smooth muscle contraction, vasodilation and capillary permeability.
Product References
- Actions of pure bradykinin: D.F. Elliott, et al.; J. Physiol. 153, 473 (1960)
- The discovery of nitric oxide as the endogenous nitrovasodilator: S. Moncada, et al.; Hypertension 12, 365 (1988)
- Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991)
- Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996)
- Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts: Z.K. Pan, et al.; J. Clin. Invest. 98, 2042 (1996)
- Bradykinin and nitric oxide in infectious disease and cancer: H. Maeda, et al.; Immunopharmacol. 33, 222 (1996)
- Bradykinin receptors and their antagonists: D. Regoli, et al.; Eur. J. Pharmacol. 348, 1 (1998)
- Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001)
- International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences: L.M. Leeb-Lundberg, et al.; Pharmacol. Rev. 57, 27 (2005)
- Formation of bradykinin: a major contributor to the innate inflammatory response: K. Joseph & A.P. Kaplan; Adv. Immunol. 86, 159 (2005)
- Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease: W.M. Abraham, et al.; Eur. J. Pharmacol. 533, 215 (2006)
- Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006)
- Multifunctional effects of bradykinin on glial cells in relation to potential anti-inflammatory effects: M. Noda, et al.; Neurochem. Int. 51, 185 (2007)
- Pathogenic mechanisms of bradykinin mediated diseases: Dysregulation of an innate inflammatory pathway: A.P. Kaplan & K. Joseph; Adv. Immunol. 121, 41 (2014)