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AdipoGen Life Sciences
Z-Leu-Leu-Nva-CHO [MG-115]
25
CHF
CHF 25.00
In stock
AG-CP3-0015-M0011 mgCHF 25.00
AG-CP3-0015-M0055 mgCHF 100.00
| Product Details | |
|---|---|
| Synonyms | Z-LLNva-CHO; Proteasome Inhibitor |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H39N3O5 |
| MW | 461.6 |
| Sequence |
Z-Leu-Leu-Nva-aldehyde |
| CAS | 133407-86-0 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in DMSO. |
| Other Product Data |
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect. |
| InChi Key | QEJRGURBLQWEOU-FKBYEOEOSA-N |
| Smiles | [H]C(=O)[C@H](CCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome.
- Calpain and cathepsin inhibitor.
- Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway.
- Autophagy activator.
Product References
- Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids: J. Adams, et al.; Bioorg. Med. Chem. Lett. 17, 333 (1998)
- Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role: K. Yamauchi, et al.; FEBS J. 275, 1540 (2008)
- Proteasome inhibition induces stress kinase dependent transport deficits-implications for Alzheimer's disease: L. Agholme, et al.; Mol. Cell Neurosci. 58, 29 (2014)
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