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Z-VRPR-FMK

AG-CP3-0008-C500 500 µg INQ
AG-CP3-0008-M001 1 mg INQ
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Additional Information

Product Data
Synonyms Z-Val-Arg-Pro-DL-Arg-FMK . TFA
Properties
Formula C31H49FN10O6 . C2HF3O2
MW 676.8 . 114.0
CAS 1381885-28-4 (free base)
Source/Host Synthetic.
Purity ≥90% (HPLC)
Appearance White to slightly yellow solid.
Solubility Soluble in water.
Identity Determined by MS.
InChi Key DYQKGOBRZWMAHV-YTJMMMLMSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles. Hygroscopic. Protect from moisture.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
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Product Description

  • Selective cell permeable and irreversible MALT1 inhibitor.
  • Inhibits NF-κB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines.
  • Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.

Product References

  1. The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008)
  2. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma: S. Hailfinger, et al.; PNAS 106, 19947 (2009)
  3. Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2: S.I. Gringhuis, et al.; PLoS Pathogens 7, e1001259 (2011)
  4. Crystal structure of a Trypanosoma brucei metacaspase: K. McLuskey, et al.; PNAS 109, 7469 (2012)
  5. MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
  6. The protease activity of the paracaspase MALT1 is controlled by monoubiquitination: C. Pelzer, et al.; J. Immunol. 14, 337 (2012)
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