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AdipoGen Life Sciences
Q-VD-OPh
190
CHF
CHF 190.00
In stock
AG-CP3-0006-M0011 mgCHF 190.00
AG-CP3-0006-30013 x 1 mgCHF 480.00
AG-CP3-0006-M0055 mgCHF 750.00
| Product Details | |
|---|---|
| Synonyms | Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H25F2N3O6 |
| MW | 513.5 |
| CAS | 1135695-98-5 (anhydrous) |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥95% (TLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO. |
| Biological Activity |
The IC50 range for caspases -1, -3, -8, -9, -10, and -12 is 25-400 nM. |
| Other Product Data |
Q-VD-OPh does not exhibit toxic effects at typical working concentrations: 10-20 μM for in vitro cell culture applications, 10-120 (up to 1000) mg/kg for in vivo animal studies. Q-VD-OPh is a small hydrophobic compound and requires DMSO for solubilization. Stock solutions as high as 200mg/ml have been prepared in DMSO. To retain solubility in water at concentrations above 1mg/ml, 80 % DMSO is suggested. For tissue culture studies 10mM or 20mM stock solutions are prepared in DMSO and diluted 1:1000 directly into the tissue culture medium. For in vivo studies Q-VD-OPh has been administered in 80% to 100% DMSO to assure solubility at the doses given. |
| InChi Key | OOBJCYKITXPCNS-AKRCKQFNSA-N |
| Smiles | CC(C)[C@H](NC(=O)C1=CC=C2C=CC=CC2=N1)C(=O)NC(CC(O)=O)C(=O)COC1=C(F)C=CC=C1F |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group.
- The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media.
- Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction.
- Decreases proteasome activity.
- Used in apoptosis and inflammasome studies.
Product References
- Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003)
- Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender: S. Renolleau, et al.; J. Neurochem. 100, 1062 (2007)
- The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15, 1403 (2010)
- The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36, 884 (2012)
- TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP: J. Knop, et al.; Cell Death Dis. 10, 700 (2019)
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