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AdipoGen Life Sciences
DAMGO . acetate
60
CHF
CHF 60.00
In stock
AG-CP3-0005V-M0011 mgCHF 60.00
AG-CP3-0005V-M0055 mgCHF 195.00
| Product Details | |
|---|---|
| Synonyms | [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin; H-Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol . acetate; DAGO; DAMGE; Dagol; RX 783006 |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H35N5O6 . C2H4O2 |
| MW | 513.6 . 60.1 |
| CAS | 100929-53-1 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in water. |
| InChi Key | XZZYKCKUDLGXJA-NJUGUJQKSA-N |
| Smiles | O=C(NCCO)[C@@H](N(C(CNC([C@H](NC([C@@H]([NH3+])CC1=CC=C(O)C=C1)=O)C)=O)=O)C)CC2=CC=CC=C2.CC([O-])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent, selective agonist of μ-opioid receptor [1].
- Antinociceptive [2,3].
- Stimulates calcium-activated adenylyl cyclases related cAMP production [4].
- Expresses chemokines and chemokine receptors through TGF-β1 [5].
- Increases food intake of rats [6].
Product References
- DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops: T. Onogi, et al.; FEBS Lett. 357, 93 (1995)
- Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats: N. Selve, et al.; Brain Res. 735, 177 (1996)
- Long-lasting antinociceptive effect of DAMGO chloromethyl ketone in rats: G. Szabo, et al.; Peptides 20, 1321 (1999)
- The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway: V. Rubovitch, et al.; Mol. Brain Res. 110, 261 (2003)
- DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1: C. Happel, et al.; J. Leukoc. Biol. 83, 956 (2008)
- Enkephalin surges in dorsal neostriatum as a signal eat: A.G. DiFeliceantonio, et al.; Curr. Biol. 22, 1918 (2012)