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AdipoGen Life Sciences
Asialo-Ganglioside GM1
240
CHF
CHF 240.00
In stock
AG-CN2-9008-C500500 µgCHF 240.00
AG-CN2-9008-M0011 mgCHF 410.00
| Product Details | |
|---|---|
| Synonyms | Ceramide tetrahexoside; Gangliotetraosylceramide; Asialoganglioside-GM1; ASGM1 |
| Product Type | Chemical |
| Properties | |
| Formula |
C62H114N2O23 |
| MW |
1255.6 (calculated on sphingosine C18:1 and stearic acid) |
| Sequence |
Structure: GgOse4Cer; β-Gal-(1-3)-β-GalNAc-(1-4)-β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90% |
| CAS | 71012-19-6 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥98% (TLC) |
| Solubility | Soluble in chloroform:methanol (2:1). |
| Formulation | Lyophilized. |
| Endotoxin Content | Not detectable. |
| Identity | Determined by 1H-NMR, MS and HPTLC. |
| InChi Key | VELGMVLNORPMAO-QZBQRYCTSA-N |
| Smiles | [H][C@@](CO[C@@H]1O[C@@H](CO)[C@@H](O[C@@H]2OC(CO)[C@H](O[C@H]3O[C@@H](CO)[C@H](O)C(O[C@@H]4OC(CO)[C@@H](O)[C@H](O)C4O)C3NC(C)=O)[C@H](O)C2O)C(O)C1O)(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialo-ganglioside GM1 does not block the binding of cholera toxin to cellular GM1.
Product References
Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
Establishment of anti-asialo-GM1 rabbit monoclonal antibodies capable of reducing natural killer cell activity in mice PLoS One 18, e0292514 (2023)
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