AdipoGen Life Sciences

Ganglioside GD3 . disodium salt

CHF 235.00
In stock
AG-CN2-9005-C500500 µgCHF 235.00
AG-CN2-9005-M0011 mgCHF 385.00
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Product Details
Synonyms GD3 . 2Na; Disialoganglioside GD3 . 2Na
Product Type Chemical
Properties
Formula

C70H123N3O29 . 2Na

MW 1470.8 . 46.0 (calculated on sphingosine
C18:1 and stearic acid)
Sequence

Structure: α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90%

CAS 62010-37-1
Source/Host Chemicals Isolated from bovine brain.
Purity Chemicals ≥98% (TLC)
Solubility Soluble in water or chloroform:methanol (2:1).
Formulation Lyophilized.
Endotoxin Content Not detectable.
Identity Determined by 1H-NMR, MS and HTPLC.
InChi Key LGRBZCLULGFXOD-MIJDSYIJSA-L
Smiles [Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@]([H])(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@H]1[C@H](O)C(CO)O[C@@H](O[C@H]2C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]2CO)C1O)C([O-])=O)C([O-])=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD3 induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis. It modulates the activity of Src-family tyrosine kinase Lyn and cell apoptosis. It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation.

Product References
  1. Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
  2. Gangliosides and neuronal differentiation: H. Rosner, et al.; Neurochem. Int. 20, 339 (1992)
  3. Ganglioside GD3 as a raft component in cell death regulation: M. Sorice, et al.; Anticancer Agents Med. Chem. 12, 376 (2012)
  4. Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones: N. Sekino-Suzuki, et al.; J. Neurochem. 124, 514 (2013)
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