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Neobavaisoflavone

CHF 220.00
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AG-CN2-0498-M0011 mgCHF 220.00
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Product Details
Synonyms 7-Hydroxy-3-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-4H-1-benzopyran-4-one; 3'-Prenyldaidzein
Product Type Chemical
Properties
Formula

C20H18O4

MW 322.4
CAS 41060-15-5
Source/Host Chemicals Isolated from Psoralea corylifolia sp.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, ethanol or methanol.
Identity Determined by 1H-NMR and MS.
InChi Key OBGPEBYHGIUFBN-UHFFFAOYSA-N
Smiles OC1=CC=C(C(C(C2=CC=C(O)C(C/C=C(C)/C)=C2)=CO3)=O)C3=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
Description
  • Antibiotic. Antibacterial and antifungal compound. Displays antibiotic activity against Gram-negative multidrug resistant bacteria.
  • Anticancer compound. DNA polymerase inhibitor. Enhances TRAIL-induced apoptosis via inhibition of metastasis.
  • Anti-inflammatory agent inhibiting IL-6-induced STAT3 activation and phosphorylation.
  • Platelet aggregation inhibitor.
  • Human carboxylesterase 1&2 and UDP-glucuronosyltransferase 1A1 inhibitor, enzymes important in drug metabolism.
  • Antioxidant. Inhibits the production of nitric oxide (NO), reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • Neuroprotective. Exerts protective effects against H2O2-induced neuronal cell damage.
  • Shows osteogenic acitivty.
Product References
  1. Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994)
  2. Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996)
  3. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998)
  4. Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007)
  5. The combination of TRAIL and isoflavones enhances apoptosis in cancer cells: J. Bronikowska, et al.; Molecules 15, 2000 (2010)
  6. Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages: E. Szliszka, et al.; Molecules 16, 3701 (2011)
  7. Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells: M.-J. Don, et al.; Phytomed. 19, 551, (2012)
  8. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation: S.W. Lee, et al.; Planta Med. 78, 903 (2012)
  9. Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells: Y.J. Kim, et al.; Life Sci. 95, 101 (2014)
  10. Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells: V. Kuete, et al.; Phytomed. 21, 682 (2014)
  11. Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes: A.T. Mbaveng, et al.; SpringerPus 4, 823 (2015)
  12. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2: Y.G. Li, et al.; Fitoterapia 101, 99 (2015)
  13. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi): X.X. Wang, et al.; Toxicol. Appl. Pharmacol. 289, 70 (2015)
  14. Quantitative analysis of Psoralea corylifolia L. and its neuroprotective and anti-neuroinflammatory effects in HT22 hippocampal cells and BV-2 microglia: Y.J. Kim, et al.; Molecules 21, e2076 (2016)
  15. Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1): D.X. Sun, et al.; Xenobiotica 46, 503 (2016)
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