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Incensol acetate

AG-CN2-0484-M001 1 mg INQ
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Product Data
Synonyms (+)-Incensol acetate; (+)-Incensole acetate; (1R,2S,5E,9E,12S)-(9Cl)-1,5,9-Trimethyl-12-(1-methylethyl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol acetate
Properties
Formula C22H36O3
MW 348.5
CAS 34701-53-6
Source/Host Semisynthetic from incensol (isolated from Boswellia papyrifera).
Purity ≥95% (HPLC)
Appearance Oil.
Solubility Soluble in DMSO, dichloromethane or ethyl ether. Insoluble in water. Almost insoluble in ethanol or methanol.
InChi Key HVBACKJYWZTKCA-XSLBTUIJSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Component of the frankincense essential oil.
  • Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. Less powerful TRPV3 agonist than incensol (Prod. No. AG-CN2-0482).
  • Shows in vivo neuroprotective properties. Causes anxiolytic-like and antidepressive-like behavioral effects in wild-type (WT) mice.
  • Anti-inflammatory agent.
  • Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.

Product References

  1. Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri: T. Akihisa, et al.; Biol. Pharm. Bull. 29, 1976 (2006)
  2. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation: A. Moussaieff, et al.; Mol. Pharmacol. 72, 1657 (2007)
  3. Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii: A. Moussaieff, et al.; J. Cereb. Blood Flow Metab. 28, 1341 (2008)
  4. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain: A. Moussaieff, et al.; FASEB J. 22, 3024 (2008)
  5. Protective effects of incensole acetate on cerebral ischemic injury: A. Moussaieff, et al.; Brain Res. 1443, 89 (2012)
  6. Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals: A. Moussaieff, et al.; J. Psychopharmacol. 26, 1584 (2012)
  7. Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity: S.I. Ali, et al.; Nat. Prod. Commun. 8, 1365 (2013)
  8. Neuroactive and anti-inflammatory frankincense cembranes: A structure-activity study: F. Pollastro, et al.; J. Nat. Prod. 79, 1762 (2016)
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