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Betulin

AG-CN2-0476-M250 250 mg INQ
AG-CN2-0476-G001 1 g INQ
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Additional Information

Product Data
Synonyms Betulinol; Trochol; NSC 4644
Properties
Formula C30H50O2
MW 442.7
Merck Index 14: 1198
CAS 473-98-3
RTECS OK5755000
Source/Host Isolated from Betulaceae family tree bark.
Purity ≥98% (NMR)
Appearance White solid.
Solubility Soluble in DMSO, DMF or ethanol.
Identity Determined by 1H-NMR.
InChi Key FVWJYYTZTCVBKE-ROUWMTJPSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
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Product Description

  • Specific SREBPs (sterol regulatory element-binding proteins) inhibitor. Inhibits ER-Golgi translocation of SREBPs through binding to SCAP in an INSIG-dependent manner.
  • Improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Lowers cholesterol levels through inhibition of SREBP-2 activation. Reduces weight gain and adipose tissue size in vivo. Increases oxygen consumption and energy expenditure. Increases UCP1/2 levels in brown adipose tissue (BAT) after cold stimulation.
  • Anticancer compound. Apoptosis inducer. DNA topoisomerase II inhibitor.
  • Anti-inflammatory compound. Shown to inhibit LPS-induced NO production through the TLR4/NF-κB signaling pathway.
  • Antiviral compound.

Product References

  1. Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity: S. Wada, et al.; J. Nat. Prod. 64, 1545 (2001)
  2. The synergistic effects of betulin with acyclovir against herpes simplex viruses: Y. Gong, et al.; Antiviral Res. 64, 127 (2004)
  3. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques: J.J. Tang, et al.; Cell Metab. 13, 44 (2011)
  4. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products: J.R. Krycer, et al.; Biochem. J. 446, 191 (2012)
  5. Targeting SREBPs for treatment of the metabolic syndrome: S.M. Soyal, et al.; Trends Pharmacol. Sci. 36, 406 (2015)
  6. Induction of apoptotic cell death by betulin in multidrug-resistant human renal carcinoma cells: N.H. Yim, et al.; Oncol. Rep. 34, 1058 (2015)
  7. Comprehensive review on betulin as a potent anticancer agent: S.K. Krol, et al.; Biomed. Res. Int. 2015 (Review)
  8. Betulin derivatives effectively suppress inflammation in vitro and in vivo: M. Laavola, et al.; J. Nat. Prod. 79, 274 (2016)
  9. Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway: H. Zhao, et al.; Life Sci. 144, 185 (2016)
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