AdipoGen Life Sciences

T-2 Toxin

CHF 85.00
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AG-CN2-0473-M0011 mgCHF 85.00
AG-CN2-0473-M0055 mgCHF 340.00
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Product Details
Synonyms Epoxytrichothecene; Fusariotoxin T-2; Insariotoxin; Mycotoxin T-2; NSC 138780
Product Type Chemical
Properties
Formula

C24H34O9

MW 466.5
CAS 21259-20-1
RTECS YD0100000
Source/Host Chemicals Isolated from fungus Fusarium tricinctum.
Purity Chemicals ≥98% (TLC)
Appearance White solid.
Solubility Soluble in DMSO (30mg/ml), ethanol (20mg/ml) or dichloromethane.
InChi Key BXFOFFBJRFZBQZ-CNLOIQPPSA-N
Smiles [H][C@@]12O[C@]3([H])C=C(C)[C@H](C[C@]3(COC(C)=O)[C@@](C)([C@H](OC(C)=O)[C@H]1O)[C@]21CO1)OC(=O)CC(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Common trichothecene mycotoxin, which can infect grain crops causing alimentary toxic aleukia in humans and animals.
  • Inhibits DNA and RNA synthesis in vivo and in vitro and can induce apoptosis. In vivo the compound rapidly metabolizes to HT-2 mycotoxin (a major metabolite).
  • Inhibits protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs.
  • Interferes with the metabolism of membrane phospholipids and increases liver lipid peroxides.
  • Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.
  • Reactive oxygen species (ROS) inducer.
Product References
  1. The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron 24, 3329 (1968)
  2. Measurement of the stability of T-2 toxin in aqueous solution: J. Mary, et al.; Chem. Res. Tox. 6, 524 (1993)
  3. T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol. 49, 387 (1997)
  4. Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997)
  5. T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998)
  6. Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats: J. Wang, et al.; Food Chem. Toxicol. 36, 955 (1998)
  7. Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006)
  8. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways: K. Doi & K. Uetsuka; Int. J. Mol. Sci. 12, 5213 (2011)
  9. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods: Y. Li, et al.; J. Agric. Food Chem. 59, 3441 (2011)
  10. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig: J. Seeboth, et al.; Vet. Res. 43, 1 (2012)
  11. Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update: Q.H. Wu, et al.; Arch. Toxicol. 88, 1309 (2014)
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