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(-)-Viriditoxin

AG-CN2-0471-C500 500 µg INQ
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Additional Information

Product Data
Synonyms (M)-Viriditoxin; SC-28762
Properties
Formula C34H30O14
MW 662.6
CAS 1381782-08-6
Source/Host Isolated from fungus Aspergillus sp.
Purity ≥98% (HPLC)
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Identity Determined by 1H-NMR.
InChi Key GMCZVCXZGZGZPX-HOTGVXAUSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Antibiotic. Exhibits broad activity against Gram-positive bacteria.
  • Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml).
  • Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells.
  • Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.

Product References

  1. Viriditoxin production by Aspergillus viridi-nutans and related species: E.B. Lillehoj & M.S. Milburn; Appl. Microbiol. 26, 202 (1973)
  2. Metabolic products from Spicaria divaricata NRRL 5771: J. Jiu S. Mizuba; J. Antibiot. (Tokyo) 27, 760 (1974)
  3. Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria: D.T. Wong & R.L. Hamill; BBRC 71, 332 (1976)
  4. Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics: J. Wang, et al.; J. Biol. Chem. 278, 44424 (2003)
  5. Second-Generation Synthesis of (-)-Viriditoxin: C.I. Grove & J.T. Shaw; Synthesis 2012, 362 (2012)
  6. Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells: S. Kundu, et al.; Int. J. Oncol. 45, 2331 (2014)
  7. A twist of nature - the significance of atropisomers in biological systems: J.E. Smyth, et al.; Nat. Prod. Rep. 32, 1562 (2015)
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