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AdipoGen Life Sciences
Artesunate
70
CHF
CHF 70.00
In stock
AG-CN2-0469-M100100 mgCHF 70.00
AG-CN2-0469-M500500 mgCHF 210.00
AG-CN2-0469-G0011 gCHF 370.00
| Product Details | |
|---|---|
| Synonyms | Artesunic acid; Qinghaozhi |
| Product Type | Chemical |
| Properties | |
| Formula |
C19H28O8 |
| MW | 384.4 |
| CAS | 88495-63-0 |
| Source/Host Chemicals | Semi-synthetic derivative of artemisinin originally isolated from Artemisia annua. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO or ethanol. Sparingly soluble in aqueous buffers. |
| InChi Key | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
| Smiles | [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(O[C@@H](OC(=O)CCC(O)=O)[C@@H]2C)O4 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from moisture and oxygen. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Semi-synthetic derivative of artemisinin.
- Anti-malaria.
- Anti-schistosomiasis.
- Inhibitor of human cytomegalovirus (CMV).
- Apoptosis inducer.
- Anti-cancer.
- Immunosuppressant.
- Inhibits production of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).
- Functional ARX inhibitor.
- Enhancer of GABAA signalling.
- Targets Gephyrin.
- Inducer of glucose-6-phosphate dehydrogenase (G6PDH) activity (25fold), the rate limiting enzyme of the pentose phosphate pathway (PPP).
- Sown to have anti-SARS-CoV-2 activity with an EC50 of 12.98 ± 5.30μM, and beeing potentially useful in the treatment of COVID-19.
Product References
- The antimalarial and toxic effect of artesunate on animal models: J. Tradit. Chin. Med. 2, 99 (1982)
- Prevention of red cell lysis in artesunate-treated rats: A role for glucose-6-phosphate dehydrogenase: T.M. Salman; Afr. J. Biotech. 8, 139 (2008)
- Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis: R. Liu, et al.; Parasit. Vectors 4, 201 (2011)
- Evaluation of the immunosuppressive activity of artesunate in vitro and in vivo: T. Li, et al.; Int. Immunopharmacol. 16, 306 (2013)
- Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation: S. Roy, et al.; Antimicrob. Agents Chemother. 59, 3870 (2015)
- Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis: D.E. Jeong, et al.; Oncotarget 6, 33046 (2015)
- Artemisinins target GABAA receptor signaling and impair α cell identity: J. Li, et al.; Cell 168, 86 (2017)
- Anti-SARS-CoV-2 Potential of Artemisinins In Vitro: R. Cao, et al.; ACS Infect. Dis. 6, 2524 (2020)
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