AdipoGen Life Sciences

Dihydroartemisinin

CHF 60.00
In stock
AG-CN2-0468-M05050 mgCHF 60.00
AG-CN2-0468-M250250 mgCHF 130.00
AG-CN2-0468-G0011 gCHF 230.00
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Product Details
Synonyms Dihydroqinghaosu; Artenimol; DHA
Product Type Chemical
Properties
Formula

C15H24O5

MW 284.3
CAS 71939-50-9
RTECS KD4165550
Source/Host Chemicals Isolated from Artemisia annua.
Purity Chemicals ≥98% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO or ethanol.
InChi Key BJDCWCLMFKKGEE-ISOSDAIHSA-N
Smiles [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(O[C@H](O)[C@@H]2C)O4
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from moisture and oxygen.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Active metabolite of artemisinin.
  • Anti-malaria (Plasmodium).
  • Anti-schistosoma.
  • Apoptosis inducer.
  • Anti-cancer.
  • Anti-inflammatory
  • Inhibits production of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).
  • Autophagy inducer.
  • Functional ARX inhibitor.
  • Enhancer of GABAA signalling.
  • Targets Gephyrin.
  • Sown to have anti-SARS-CoV-2 activity with an EC50 of 13.31 ± 1.24μM, and beeing potentially useful in the treatment of COVID-19.
Product References
  1. Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985)
  2. Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model: C. J. Janse, et al.; Int. J. Parasitol. 24, 589 (1994)
  3. The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu: Y. Tu; SE Asian J. Trop. Med. Publ. Health 35, 250 (2004)
  4. Artemisinin induces apoptosis in human cancer cells: N.P. Singh & H.C. Lai; Anticancer Res. 24, 2277 (2004)
  5. Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells: C. Zhu, et al.; PLoS One 7, e35125 (2012)
  6. In vivo activity of dihydroartemisinin against Schistosoma mansoni schistosomula in mice: H.J. Li, et al.; SE Asian J. Trop. Med. Publ. Health 44, 379 (2013)
  7. Differential effect of artemisinin against cancer cell lines: M. Tilaoui, et al.; Nat. Prod. Bioprospect. 4, 189 (2014)
  8. Dihydroartemisinin supresses inflammation and fibrosis in bleomycine-induced pulmonary fibrosis in rats: D. Yang, et al.; Int. J. Clin. Exp. Pathol. 8, 1270 (2015)
  9. Dihydroartemisinin increases temozolomide efficacy in glioma cells by inducing autophagy: Z.S. Zhang, et al.; Oncol. Lett. 10, 379 (2015)
  10. Artemisinins target GABAA receptor signaling and impair α cell identity: J. Li, et al.; Cell 168, 86 (2017)
  11. EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites: P. Mesén-Ramírez, et al.; PLoS Biol. 17, e3000473 (2019)
  12. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro: R. Cao, et al.; ACS Infect. Dis. 6, 2524 (2020)
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