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AdipoGen Life Sciences
Artemisinin
55
CHF
CHF 55.00
In stock
AG-CN2-0467-M100100 mgCHF 55.00
AG-CN2-0467-M500500 mgCHF 130.00
AG-CN2-0467-G0011 gCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Qinghaosu; Arteannuin |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H22O5 |
| MW | 282.3 |
| CAS | 63968-64-9 |
| RTECS | KD4170000 |
| Source/Host Chemicals | Isolated from Artemisia annua. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | BLUAFEHZUWYNDE-NNWCWBAJSA-N |
| Smiles | [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(OC(=O)[C@@H]2C)O4 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from moisture and oxygen. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anti-malaria.
- Apoptosis inducer.
- Anti-cancer.
- Inhibits production of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).
- Functional ARX inhibitor. Enhancer of GABAA signaling. Shown to promote the in vivo conversion of pancreatic α cells into functional β-like cells through enhanced GABA signaling and may have potential as a therapeutic for diabetes.
- Targets Gephyrin.
Product References
- Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985)
- The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu: Y. Tu; SE Asian J. Trop. Med. Publ. Health 35, 250 (2004)
- Artemisinin induces apoptosis in human cancer cells: N.P. Singh & H.C. Lai; Anticancer Res. 24, 2277 (2004)
- Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells: C. Zhu, et al.; PLoS One 7, e35125 (2012)
- Differential effect of artemisinin against cancer cell lines: M. Tilaoui, et al.; Nat. Prod. Bioprospect. 4, 189 (2014)
- Artemisinins target GABAA receptor signaling and impair α cell identity: J. Li, et al.; Cell 168, 86 (2017)
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