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Convulxin

AG-CN2-0465-C050 50 µg INQ
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Additional Information

Product Data
Synonyms CVX
Properties
MW ~84kDa
CAS 37206-04-5
Source/Host Isolated from Crotalus durissus terrificus snake venom.
Purity Partially purified by multi-step chromatography.
Appearance Lyophilized.
Solubility Soluble in organic buffer (HEPES).
Reconstitution Reconstitute in 10mM HEPES buffer, pH 7.2. (We recommend adding a carrier protein such as BSA to the reconstitution buffer and any subsequent dilution buffers to prevent absorption on plastic surfaces.)
Biological Activity <50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
Other Product Data Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors.
  • Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor γ-chain and activates p72SYK that is critical for downstream activation of platelets.
  • Causes cardiovascular and respiratory disturbances.
  • Prostaglandins are strong inhibitors of convulxin-induced aggregation.
  • Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous α and β chains. The heterodimers are additionally linked by disulfide bridges to form cyclic α(4)β(4)heterotetramers.

Product References

  1. Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981)
  2. Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets: I.M. Francischetti, et al.; Toxicon 35, 1217 (1997)
  3. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997)
  4. Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998)
  5. Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000)
  6. Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin: B.T. Atkinson, et al.; Eur. J. Biochem. 268, 5242 (2001)
  7. Convulxin binding to platelet receptor GPVI: competition with collagen related peptides: F. Niedergang, et al.; BBRC 273, 246 (2002)
  8. Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003)
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