Call +41-61-926-60-40 Fax +41-61-926-60-49

Celastrol

AG-CN2-0460-M005 5 mg INQ
AG-CN2-0460-M010 10 mg INQ
AG-CN2-0460-M050 50 mg INQ
Actions
Select size:

* Required Fields

Amount:
Add to Cart
Call +41-61-926-60-40
Fax +41-61-926-60-49
Contact Us!

Additional Information

Product Data
Synonyms Tripterine; NSC 70931
Properties
Formula C29H38O4
MW 450.6
Merck Index 14: 10370
CAS 34157-83-0
RTECS YJ7900000
Source/Host Isolated from Tripterygium wilfordii.
Purity ≥98% (HPLC)
Appearance Red solid.
Solubility Soluble in DMSO, ethanol or dimethylformamide. Insoluble in water.
InChi Key KQJSQWZMSAGSHN-JJWQIEBTSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download Document Download

Product Description

  • Anti-obesity agent. Potent leptin sensitizer.
  • Antioxidant.
  • Potent lipid peroxidation inhibitor.
  • NADPH oxidases (NOX1, 2, 4 and 5) inhibitor.
  • Anti-inflammatory. NF-κB inhibitor.
  • HSP90 inhibitor and HSP70 inducer.
  • Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways.
  • Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1α pathway.
  • Topoisomerase II inhibitor.
  • 20S proteasome chymotrypsin-like activity inhibitor.
  • Potential antiviral and anti-Alzheimer's agent.

Product References

  1. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990)
  2. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001)
  3. Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002)
  4. Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003)
  5. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid: J.H. Lee, et al.; Biochem. Pharmacol. 72, 1311 (2006)
  6. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006)
  7. Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation: Z. Lu, et al.; Cancer Lett. 290, 182 (2010)
  8. Celastrol: Molecular targets of Thunder God Vine: A. Salminen, et al.; BBRC 394, 439 (2010) (Review)
  9. Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway: H. Zhu, et al.; J. Pharmacol. Exp. Ther. 334, 489 (2010)
  10. Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway: L. Huang, et al.; Int. J. Mol. Med. 27, 407 (2011)
  11. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action: V. Jaquet, et al.; Br. J. Pharmacol. 164, 507 (2011)
  12. Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication: V. Narayan, et al.; J. Mol. Biol. 410, 972 (2011)
  13. Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways: R. Kannaiyan, et al.; Apoptosis 16, 1028 (2011)
  14. Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice: J.E. Kim, et al.; PLoS One 8, e62068 (2013)
  15. Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways: T. Gwag, et al.; Arch. Biochem. Biophys. 537, 21 (2013)
  16. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study: H.Y. Li, et al.; Cell Death Dis. 6, e1604 (2015)
  17. Treatment of obesity with celastrol: J. Liu, et al.; Cell 161, 999 (2015)
No reviews for this product yet.