AdipoGen Life Sciences

Aerothionin

CHF 180.00
In stock
AG-CN2-0453-M0011 mgCHF 180.00
More Information
Product Details
Synonyms NSC177380
Product Type Chemical
Properties
Formula

C24H26Br4N4O8

MW 818.1
CAS 28714-26-3
Source/Host Chemicals Isolated from Suberea sp.
Purity Chemicals ≥98% (HPLC)
Appearance Colorless to white adhered film.
Solubility Soluble in DMSO or 100% ethanol.
Identity Determined by 1H-NMR and MS.
InChi Key BJWQSQOWGBUSFC-UWXQAFAOSA-N
Smiles COC1=C(Br)[C@H](O)[C@]2(CC(=NO2)C(=O)NCCCCNC(=O)C2=NO[C@@]3(C2)C=C(Br)C(OC)=C(Br)[C@@H]3O)C=C1Br
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Antibiotic.
  • Anti-mycobacterial.
Product References
  1. Aerothionin, a tetrabromo-compound from Aplysina aerophoba and Verongia thiona: E. Fattorusso, et al.; J. Chem. Soc. D: Chem. Commun. 12, 752 (1970)
  2. Aerothionin and homoaerothionin: Two tetra bromo spirocyclohexadienylisoxazoles from Verongia sponges: K. Moody, et al.; J. C. S. Perkin Trans. I, 18 (1972)
  3. An x-ray study of aerothionin from Aplysina fistularis: J.A. McMillan, et al.; Tetrahedron Lett. 22, 39 (1981).
  4. Chemistry of sponges, VII. 11,19-Dideoxyfistularin 3 and 11-Hydroxyaerothionin, bromotyrosine derivatives from Pseudoceratina durissima: M.R. Kernan & R.C. Cambie; J. Nat. Prod. 53, 615 (1990)
  5. Chemistry of Verongida sponges, II. Constituents of the Caribbean sponge Aplysina fistularis forma fulva: P. Ciminiello, et al.; J. Nat. Prod. 57, 705 (1994)
  6. Aerothionin, a bromotyrosine derivative with antimycobacterial activity from the marine sponge Aplysina gerardogreeni (Demospongia): R. Encarnacion-Dimayuga, et al.; Pharm. Biol. 41, 384 (2003)
  7. Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative: T. Ogamino, et al.; Tetradedron Lett. 47, 727 (2006)
  8. Bioactive constituents from the marine crinoid Himerometra magnipinna: N. Shao, et al.; J. Nat. Prod. 70, 869 (2007)
  9. Bioactive brominated metabolites from the Red Sea sponge Suberea mollis: M.I. Abou-Shoer, et al.; J. Nat. Prod. 71, 1464 (2008)
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