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Triptolide

AG-CN2-0448-M001 1 mg INQ
AG-CN2-0448-M005 5 mg INQ
AG-CN2-0448-M010 10 mg INQ
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Additional Information

Product Data
Synonyms PG 490; NSC163062
Properties
Formula C20H24O6
MW 360.4
CAS 38748-32-2
RTECS YK7751000
Source/Host Isolated from Tripterygium sp.
Purity ≥98% (HPLC)
Appearance Crystalline solid.
Solubility Soluble in DMSO. Sparingly soluble in ethanol.
Identity Determined by 1H-NMR.
InChi Key DFBIRQPKNDILPW-KTGKZQHOSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Keep under inert gas. Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Potent immunosuppressant with anti-inflammatory and antitumor properties.
  • Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators.
  • Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH).
  • Human dCTP pyrophosphatase 1 inhibitor.
  • Interferes with a number of transcription factors including p53, NF-κB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1).
  • Shown to inhibit aromatase activity.
  • Shows antifertility activity and antipolycystic kidney disease effects.

Product References

  1. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii: S.M. Kupchan, et al.; JACS 94, 7194 (1972)
  2. Triptolide: a potential male contraceptive: Y. Lue, et al.; J. Androl. 19, 479 (1998)
  3. Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998)
  4. Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes: H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000)
  5. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F: B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review)
  6. Triptolide inhibits the growth and metastasis of solid tumors: S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003)
  7. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006)
  8. Triptolide alters mitochondrial functions: Y. Su, et al.; Adv. Exp. Med. Biol. 599, 139 (2007)
  9. Triptolide functions as a potent angiogenesis inhibitor: M.F. He, et al.; Int. J. Cancer 126, 266 (2010)
  10. Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors: S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011)
  11. RNA polymerase - an important molecular target of triptolide in cancer cells: J. Pan; Cancer Lett. 292, 149 (2010) (Review)
  12. Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways: N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010)
  13. Triptolide and its expanding multiple pharmacological functions: Q. Liu; Int. Immunopharmacol. 11, 377 (2011) (Review)
  14. XPB, a subunit of TFIIH, is a target of the natural product triptolide: D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011)
  15. Triptolide directly inhibits dCTP pyrophosphatase: T.W. Corson, et al.; Chembiochem 12, 1767 (2011)
  16. Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II): Y. Wang, et al.; PLoS One 6, e23993 (2011)
  17. Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms: Z.L. Zhou, et al.; Nat. Prod. Rep. 29, 457 (2012)
  18. Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells: J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011)
  19. TAB1: a target of triptolide in macrophages: Y. Lu, et al.; Chem. Biol. 21, 246 (2014)
  20. Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway: H. Shao, et al.; Exp. Ther. Med. 8, 505 (2014)
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