AdipoGen Life Sciences

Cyclosporin D

CHF 110.00
In stock
AG-CN2-0445-M0011 mgCHF 110.00
AG-CN2-0445-M0055 mgCHF 250.00
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Product Details
Synonyms Val2-Cyclosporine; CsD
Product Type Chemical
Properties
Formula

C63H113N11O12

MW 1216.7
Merck Index 14: 2752
CAS 63775-96-2
Source/Host Chemicals Isolated from Fusarium solani.
Purity Chemicals ≥97% (HPLC)
Appearance White solid.
Solubility Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
InChi Key ZNVBEWJRWHNZMK-AHWIEGLVSA-N
Smiles [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(NC1=O)C(C)C)C(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo.
  • Antifungal.
  • Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079).
  • Moderate inhibitor of formyl peptide-induced superoxide formation.
Product References
  1. Effect of column temperature and eluent flow rate on the high performance liquid chromatographic analysis of cyclosporin a and d: K.A. Mereish & C.T. Ueda; Pharm. Res. 1, 245 (1984)
  2. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)
  3. Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wentzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)
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