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Cinnamtannin B-1

AG-CN2-0428-M005 5 mg INQ
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Additional Information

Product Data
Synonyms Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin; Cinnamtannin B1; CB1
Properties
Formula C45H36O18
MW 864.7
CAS 88082-60-4
Source/Host Isolated from Laurus nobilis L.
Purity ≥95% (HPLC)
Appearance Brown solid.
Solubility Soluble in ethanol, methanol or a DMSO:water mixture.
Other Product Data Stable in methanol solution for up to 4 weeks when stored at -20°C.
InChi Key BYSRPHRKESMCPO-LQNPQWRQSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Keep under inert gas. Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • A-Type proanthocyanidine.
  • Selective cytotoxic agent [1].
  • Potent antioxidant [2, 4, 8, 9].
  • Lipid peroxidation inhibitor [2].
  • Antidiabetic, with similar effects to insulin activity in adipogenesis [3].
  • Free radical scavenger [4].
  • Antithrombotic. Inhibits platelet aggregation [5, 6, 8].
  • Apoptosis inhibitor [7, 12].
  • Reduces intracellular Ca(2+) overload and ROS production [8, 10].
  • Antibacterial [9].
  • Cyclooxygenase-2 (COX-2) inhibitor in vitro [11].
  • LDL oxidation inhibitor [13].

Product References

  1. Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992)
  2. Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999)
  3. Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004)
  4. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006)
  5. Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007)
  6. Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007)
  7. Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007)
  8. Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J.J. López, et al.; Life Sci. 82, 977 (2008)
  9. Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties : T.O. Idowu, et al.; Phytochemistry 71, 2092 (2010)
  10. Effect of cinnamtannin B-1 on cholecystokinin-8-evoked responses in mouse pancreatic acinar cells: R. Rivera-Barreno, et al.; Clin. Exp. Pharmacol. Physiol. 37, 980 (2010)
  11. Bioactive A-type proanthocyanidins from Cinnamomum cassia: K.B. Killday, et al.; J. Nat. Prod. 74, 1833 (2011)
  12. Cinnamtannin B-1 regulates cell proliferation of spinal cord astrocytes and protects the cell from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis: Z. Chi, et al.; Int. J. Mol. Sci. 14, 15827 (2013)
  13. Flavonoids from Lindera glauca Blume as low-density lipoprotein oxidation inhibitors: G.W. Huh, et al.; Nat. Prod. Res. 28, 831 (2014)
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