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AdipoGen Life Sciences
Wedelolactone
90
CHF
CHF 90.00
In stock
AG-CN2-0424-M0011 mgCHF 90.00
AG-CN2-0424-M0055 mgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | 7-Methoxy-5,11,12-trihydroxy-coumestan; WDL |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H10O7 |
| MW | 314.2 |
| CAS | 524-12-9 |
| Source/Host Chemicals | Isolated from Eclipta prostrata. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow to amber crystalline powder. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| Smiles | COC1=CC(O)=C2C3=C(C4=C(O3)C=C(O)C(O)=C4)C(=O)OC2=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, selective and irreversible IKKα and β kinase activity inhibitor [2].
- NF-κB inhibitor. Blocks phosphorylation and degradation of IκBα [2].
- Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor [1, 2].
- Anti-inflammatory [2].
- HIV-1 integrase inhibitor [3].
- Anticancer and antiproliferative compound [4, 5].
- Modulates androgen receptor (AR) activation [4].
- Apoptosis inducer via downregulation of PKCε [5, 9].
- DNA topoisomerase IIα inhibitor [6].
- G protein-coupled receptor-35 (GPR35) agonist [7].
- Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway [8].
- STAT1 protein dephosphorylation inhibitor [10].
- Antifibrotic [11].
Product References
- Wedelolactone and coumestan derivatives as new antihepatotoxic and antiphlogistic principles: S.M. Wong, et al.; Arzneimittelforschung 38, 661 (1988)
- Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex: M. Kobori, et al.; Cell Death Differ. 11, 123 (2004)
- HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata: S. Tewtrakul, et al.; Phytother. Res. 21, 1092 (2007)
- Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells: F.M. Lin, et al.; Carcinogenesis 28, 2521 (2007)
- Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo: A.I. Idris, et al.; Mol. Cancer Ther. 8, 2339 (2009)
- Inhibition of topoisomerase IIα: novel function of wedelolactone: P. Benes, et al.; Cancer Lett. 303, 29 (2011)
- Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists: H. Deng & Y. Fang; Pharmacology 89, 211 (2012)
- Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells: S. Lim, et al.; J. Cell Biochem. 113, 3436 (2012)
- Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt: S. Sarveswaran, et al.; Int. J. Oncol. 41, 2191 (2012)
- Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation: Z. Chen, et al.; J. Biol. Chem. 288, 14417 (2013)
- Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2: Y. Xia, et al.; Eur. J. Pharmacol. 714, 105 (2013)
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