Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Papaverine . hydrochloride
30
CHF
CHF 30.00
In stock
AG-CN2-0414-G0011 gCHF 30.00
AG-CN2-0414-G0055 gCHF 90.00
| Product Details | |
|---|---|
| Synonyms | 6,7-Dimethoxy-1-veratrylisoquinoline; NSC 35443; NCI-C56359 |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H21NO4 . HCl |
| MW | 339.4 . 36.5 |
| CAS | 61-25-6 |
| RTECS | NW8575000 |
| Source/Host Chemicals | Synthetic. Originally isolated from Papaver somniferum. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. |
| Identity | Identity determined by 1H-NMR. |
| InChi Key | UOTMYNBWXDUBNX-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Smooth muscle relaxant and vasodilator [4].
- Phosphodiesterase PDE10A inhibitor [3,5,6].
- Antiviral [1,2].
- Antipsychotic [3].
- Potential inducer of browning in WAT.
Product References
- Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells: Y. Yoshikawa & K. Yamanouchi; J. Virol. 50, 489 (1984)
- Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function: M. Nokta, et al.; Immunopharmacol. 26, 181 (1993)
- Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis: J.A. Siuciak, et al.; Neuropharmacol. 51, 386 (2006)
- The effect of papaverine on ion channels in rat basilar smooth muscle cells: D.H. Han, et al.; Neurol. Res. 29, 544 (2007)
- The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices: Y.T. Hsu, et al.; Neuropharmacol. 61, 1275 (2011)
- PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a huntington's disease mouse model: A. Giralt, et al.; Hippocampus 23, 684 (2013)
- A novel thermoregulatory role for PDE10A in mouse and human adipocytes: M.K. Hankir, et al.; EMBO Mol. Med. 8, 796 (2016)
Related Products
