AdipoGen Life Sciences

Meglumine

CHF 35.00
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AG-CN2-0413-G0011 gCHF 35.00
AG-CN2-0413-G0055 gCHF 90.00
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Product Details
Synonyms N-Methyl-D-glucamine; NSC52907; NSC7391; 1-Deoxy-1-methylaminosorbitol
Product Type Chemical
Properties
Formula

C7H17NO5

MW 195.2
Merck Index 14: 6078
CAS 6284-40-8
Source/Host Chemicals Synthetic. Amino sugar derived from sorbitol.
Purity Chemicals ≥95% (NMR)
Appearance White to off-white crystalline powder.
Solubility Soluble in DMSO or water. Slightly soluble in ethanol.
Identity Determined by 1H-NMR.
InChi Key MBBZMMPHUWSWHV-UHFFFAOYSA-N
Smiles [H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)CNC
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances.
  • Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium.
  • Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as diatrizoate meglumine and iodipamide meglumine.
  • Examples of meglumine-combined drugs are flunixin meglumine (used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis).
Product References
  1. Ternary amorphous composites of celecoxib, poly(vinyl pyrrolidone) and meglumine with enhanced solubility: P. Gupta & A.K. Bansal; Pharmazie 60, 830 (2005)
  2. Modeling of drug release from celecoxib-PVPmeglumine amorphous system: P. Gupta & A.K. Bansal; PDA. J. Pharm. Sci. Technol. 59, 346 (2005)
  3. Molecular interactions in celecoxib-PVPmeglumine amorphous system: P. Gupta & A.K. Bansal; J. Pharm. Pharmacol. 57, 303 (2005)
  4. Enhanced oral delivery of antimony from meglumine antimoniate/b-cyclodextrin nanoassemblies: F. Frezard, et al.; Int. J. Pharm. 347, 102 (2008)
  5. Generation of formaldehyde by pharmaceutical excipients and its absorption by meglumine: M. Fujita, et al.; Chem. Pharm. Bull. 57, 1096 (2009)
  6. Stabilization by meglumine of an amine compound degraded by formaldehyde in tablets: M. Fujita, et al.; Int. J. Pharm. 386, 195 (2010)
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