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AdipoGen Life Sciences
Paxilline
55
CHF
CHF 55.00
In stock
AG-CN2-0167-M0011 mgCHF 55.00
AG-CN2-0167-M0055 mgCHF 165.00
| Product Details | |
|---|---|
| Synonyms | BRN 5317894; NSC 658707 |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H33NO4 |
| MW | 435.6 |
| CAS | 57186-25-1 |
| RTECS | DJ2830000 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, methanol or ethanol (all at least 1mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| Smiles | [H][C@]12CC3=C(NC4=C3C=CC=C4)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H](C(=O)C=C3[C@]1(O)CC2)C(C)(C)O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Tremorgenic [1].
- Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels [2].
- Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)) [3].
- Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor [4].
- Liver X receptor (LXRα and LXRβ; NR1H3 and NR1H2) agonist in biochemical and in vitro cell-based assays [5].
- Anticonvulsant [6].
- Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis [7].
- Shown to protect neuronal cells against glutamate-induced cell death [8].
Product References
- A new tremorgenic metabolite from Penicillium paxilli: R.J. Cole, et al.; Can. J. Microbiol. 20, 1159 (1974)
- Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry 33, 5819 (1994)
- The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor: C.L. Longland, et al.; Eur. J. Pharmacol. 408, 219 (2000)
- The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline: J.G. Bilmen, et al.; Arch. Biochem. Biophys. 406, 55 (2002)
- A natural product ligand of the oxysterol receptor, liver X receptor: K.S. Bramlett, et al.; J. Pharmacol. Exp. Ther. 307, 291 (2003)
- Anticonvulsant effects of the BK-channel antagonist paxilline: J.J. Sheehan, et al.; Epilepsia 50, 711 (2009)
- Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5: Y.J. Kang, et al.; Exp. Mol. Med. 43, 24 (2011)
- Glutamate-induced cell death in HT22 mouse hippocampal cells is attenuated by paxilline, a BK channel inhibitor: B. Kulawiak & A. Szewczyk; Mitochondrion 12, 169 (2012)
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