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AdipoGen Life Sciences
OM173-αA
260
CHF
CHF 260.00
In stock
AG-CN2-0158-M0011 mgCHF 260.00
AG-CN2-0158-M0055 mgCHF 950.00
| Product Details | |
|---|---|
| Synonyms | Nanaomycin αA |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H16O6 |
| MW | 316.3 |
| CAS | 58286-56-9 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| InChi Key | FMEUWIKCSICJBO-DTWKUNHWSA-N |
| Smiles | COC(=O)C[C@H]1CC2=C([C@H](C)O1)C(=O)C1=C(O)C=CC=C1C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1-3].
- Antimycoplasma [1, 3, 4].
- Antifungal compound [1, 3].
- Anti-malarial agent [5].
- Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6].
- Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines [6-8].
- Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor [8].
Product References
- Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties: H. Tanaka, et al.; J. Antibiot. 28, 860 (1975)
- Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis: H. Tanaka, et al.; J. Antibiot. 28, 868 (1975)
- Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives: H. Tanaka, et al.; J. Antibiot. 28, 925 (1975)
- OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties: Y. Iway, et al.; J. Antibiot. 36, 1268 (1983)
- Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol: Y. Tanaka, et al.; J. Antibiot. 52, 880 (1999)
- UCF76 compounds, new inhibitors of farnesyltransferase produced by Streptomyces: M. Hara, et al.; J. Antibiot. 54, 182 (2001)
- Total synthesis and development of bioactive natural products: T. Kuniaki; Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 84, 87 (2008)
- Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells: D. Kuck, et al.; Mol. Cancer Ther. 9, 3015 (2010)
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