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AdipoGen Life Sciences
Territrem B
160
CHF
CHF 160.00
In stock
AG-CN2-0142-C500500 µgCHF 160.00
AG-CN2-0142-M0011 mgCHF 290.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C29H34O9 |
| MW | 526.6 |
| CAS | 70407-20-4 |
| RTECS | QL6284000 |
| Source/Host Chemicals | Synthetic. Originally isolated from Aspergillus terreus. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in methanol or chloroform. Insoluble in water. |
| InChi Key | PBXNNDFKPQPJBB-VJLHXPKFSA-N |
| Smiles | COC1=CC(=CC(OC)=C1OC)C1=CC2=C(C[C@@]3(O)[C@@](C)(CC[C@@]4(O)C(C)(C)C=CC(=O)[C@]34C)O2)C(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Tremorgenic mycotoxin [1, 2].
- Potent and specific, irreversible acetylcholinesterase (AChE) inhibitor [3-7].
Product References
- Territrems, tremorgenic mycotoxins of Aspergillus terreus: K.H. Ling, et al.; Appl. Environ. Microbiol. 37, 355 (1979)
- Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem B' from Aspergillus terreus: F.C. Peng, et al.; Appl. Environ. Microbiol. 49, 721 (1985)
- Effects of territrem-B on cholinergic responses of snail neuron: V.L. Arvanov, et al.; Neurosci. Lett. 152, 69 (1993)
- Acetylcholinesterase inhibition by territrem B derivatives: F.C. Peng; J. Nat. Prod. 58, 857 (1995)
- Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase: J.W. Chen & K.H. Ling; J. Biomed. Sci. 3, 54 (1996)
- Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity: F. Kuno, et al.; J. Antibiot. 49, 742 (1996)
- Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism: J.W. Chen, et al.; J. Biol. Chem. 274, 34916 (1999)
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