AdipoGen Life Sciences

Fuscin

CHF 220.00
In stock
AG-CN2-0138-M0011 mgCHF 220.00
AG-CN2-0138-MM252.5 mgCHF 460.00
More Information
Product Details
Synonyms 3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one
Product Type Chemical
Properties
Formula

C15H16O5

MW 276.3
CAS 83-85-2
Source/Host Chemicals Isolated from Oidiodendron sp.
Purity Chemicals ≥95% (HPLC)
Appearance Brown solid.
Solubility Soluble in DMSO. Insoluble in water.
InChi Key OSJKAGRXDVEZQO-UHFFFAOYSA-N
Smiles CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Mycotoxin.
  • Antibacterial agent.
  • ADP transport inhibitor. 
  • NADH dehydrogenase (NADH-Coenzyme Q oxidoreductase; Complex I) inhibitor. Inhibits mitochondrial respiration and oxidative phosphorylation (OXPHOS).
  • Human CCR5 receptor antagonist.
  • Anti-HIV compound.
Product References
  1. Fuscin, an antibacterial pigment from Oidiodendron fuscum Robak: S.E. Michael; Biochem. J. 1948, 42 (1948)
  2. Fuscin, an Inhibitor of NADH Dehydrogenase: P.M. Vignais; Inhibitors Tools in Cell Research 20, 274 (1969) 
  3. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria: K.S. Cheah; Biochim. Biophys. Acta 275, 1 (1972)
  4. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions: P.M. Vignais & P.V. Vignais; Biochim. Biophys. Acta 325, 357 (1973)
  5. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum: K. Yoganathan, et al.; J. Nat. Prod. 66, 1116 (2003)
  6. Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells: S-K. Cho, et al.; Cells 12, 384 (2023)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.