AdipoGen Life Sciences

Terpendole E

CHF 95.00
In stock
AG-CN2-0127-C250250 µgCHF 95.00
More Information
Product Details
Synonyms 1'α-Hydroxy-Paspaline
Product Type Chemical
Properties
Formula

C28H39NO3

MW 437.6
CAS 167427-23-8
Source/Host Chemicals Isolated from Albophoma yamanashiensis.
Purity Chemicals ≥95% (HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO, ethanol or methanol.
InChi Key SVYIMXYKHRBHSG-CDIJYFRTBB
Smiles [H][C@]12CC3=C(NC4=CC=CC=C34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H](C[C@@H](O)[C@@]3(C)C1([H])CC2)C(C)(C)O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 2].
  • Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) inhibitor [3-7].
  • Specific M phase inhibitor [4]. 
Product References
  1. Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
  2. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
  3. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5: J. Nakazawa, et al.; Chem. Biol. 10, 131 (2003)
  4. Development and application of bioprobes for Mammalian cell cycle analyses: H. Osada; Curr. Med. Chem. 10, 727 (2003) (Review)
  5. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly: C. Jiang, et al.; J. Mol. Model  13, 987 (2007)
  6. A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues: F. Churruca, et al.; Org. Lett. 12, 2096 (2010)
  7. Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds: S. Oishi, et al.; J. Med. Chem. 53, 5054 (2010)
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