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AG-CN2-0124-C250 250 µg $45.00
AG-CN2-0124-M001 1 mg $130.00
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Product Data
Synonyms (+)-Rugulosin; NSC 160880; NSC 249990; Radicalisin
Formula C30H22O10
MW 542.5
CAS 23537-16-8
RTECS VM1610000
Source/Host Chemicals Isolated from Penicillium sp.
Purity ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO, ethanol or methanol.
Origin Manufactured by BioLinks K.K. with courtesy strain from The Kitasato Institute.
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
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Product Description

  • Antibiotic [1].
  • Antibacteriophage. Antiviral [2].
  • Mycotoxin [3].
  • DNA replication, transcription and repair inhibitor [4].
  • Antibacterial [5].
  • RNA polymerase and ribonuclease H inhibitor [6].
  • Insecticidal. Cytotoxic [7].
  • HIV-1 integrase inhibitor [8].
  • Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity [9].
  • Potential Hsp90 inhibitor through interacting with N-Hsp90 [10].

Product References

  1. Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
  2. Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
  3. Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
  4. Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
  5. Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
  6. Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
  7. Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
  8. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
  9. New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
  10. Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)
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