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AdipoGen Life Sciences
Malformin C
140
CHF
CHF 140.00
In stock
AG-CN2-0107-C250250 µgCHF 140.00
AG-CN2-0107-M0011 mgCHF 390.00
| Product Details | |
|---|---|
| Synonyms | 5-L-Leucine-Malformin A; BRN 4896114; (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-] |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H39N5O5S2 |
| MW | 529.7 |
| CAS | 59926-78-2 |
| Source/Host Chemicals | Synthetic. Originally isolated from Aspergillus niger FKI-2342. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, methanol, ethanol or chloroform. Insoluble in water. |
| Other Product Data |
Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents. |
| InChi Key | TZODYIWCRGWHQB-TZNCUMHOSA-N |
| Smiles | CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]2CSSC[C@@H](NC1=O)C(=O)N2)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Peptide antibiotic [1].
- Induces root curvature and malformation in plants [1].
- Antibacterial [1, 2], antimalarial and antitrypanosomal [4].
- Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents [3].
Product References
- Malformin C, a new metabolite of Aspergillus niger: R.J. Anderegg, et al.; JACS 98, 3365 (1976)
- Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger: B. Kobbe, et al.; Appl. Environ. Microbiol. 33, 996 (1977)
- Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells: K. Hagimori, et al.; Biol. Pharm. Bull. 30, 1379 (2007)
- Solid-phase synthesis and biological activity of malformin C and its derivatives: Y. Kojima, et al.; J. Antibiot. (Tokyo) 62, 681 (2009)
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