AdipoGen Life Sciences

EM574

CHF 140.00
In stock
AG-CN2-0102-C250250 µgCHF 140.00
AG-CN2-0102-M0011 mgCHF 420.00
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Product Details
Synonyms Motilide; Idremcinal; 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
Product Type Chemical
Properties
Formula

C39H69NO12

MW 744.0
CAS 110480-13-2
Source/Host Chemicals Semisynthetic from erythromycin A.
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in methanol, ethanol, DMSO, chloroform, acetone, ethyl acetate or acetonitrile. Insoluble in water or hexane.
InChi Key FPBKIOZMKHHNLL-FMUXYZBNSA-N
Smiles CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Shows strong gastrointestinal motor stimulating (GMS) activity [1, 2, 5].
  • Motilin receptor agonist [3, 6].
  • Stimulates smooth muscle cell contraction [3].
  • Stimulates cholinergic neurons in a non-vagal pathway [4].
  • Enhances gastrointestinal contractile activity and accelerates gastric emptying [7, 8].
  • Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor) [9].
Product References
  1. Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. (Tokyo) 38, 1631 (1985)
  2. Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987)
  3. EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994)
  4. Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996)
  5. Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. (Tokyo) 49, 794 (1996)
  6. EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997)
  7. Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998)
  8. Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs: T. Tanaka, et al.; Dig. Dis. Sci. 44, 1100 (1999)
  9. EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor: A. Asakawa, et al.; J. Gastroenterol. Hepatol. 18, 881 (2003)
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